I’ve been playing SHCE on Win 10 using Dfend Reloaded for several years now- works great. 
Also using the SHReal mod. I play having my crew helping set the TDC, and with the navigation tools built in to the game, so maybe I’m cheating a bit. I also don’t play at 125% realism, but I have lost 50% of my career subs so far, oops. Here are a few quickly edited encounters from the last few months:
