Phobic of needles? Try jellyfish!

snowsub · 08-25-06, 08:11 AM

Lovely little fella isn't he..... Not

Quote...
The rapid onset of systemic symptoms after major jellyfish envenoming by C. fleckeri suggests that venom is "most probably introduced directly into blood vessels". Postmortem evidence from the last C. fleckeri fatality demonstrated nematocyst barbs penetrating the vascular dermis.
C. fleckeri venom has haemolytic, lethal, myotoxic and dermonecrotic effects. Current evidence suggests that the venom toxins are proteinaceous and target specific organs. Monoclonal antibodies capable of neutralising C. fleckeri-induced haemolysis did not protect against the lethal effects of venom. Several myotoxins, with molecular weights of about 600 kDa and 150 kDa, have been reported in C fleckeri venom. These toxins showed significant lethality in a mouse model of envenomation and may play a role in human cardiotoxicity. We speculate that these and other, as yet unidentified, proteins cause ion flux and transmitter release through altering cell membrane permeability, either through specific interactions with ion-channels or receptors or through non-specific interactions with cell membranes.

Charmers...

And thank god I don't live in that region

08-25-06, 08:11 AM	#1
snowsub 中国水兵 Join Date: Apr 2005 Location: Moreton bay Posts: 286 Downloads: 0 Uploads: 0	Lovely little fella isn't he..... Not Quote... The rapid onset of systemic symptoms after major jellyfish envenoming by C. fleckeri suggests that venom is "most probably introduced directly into blood vessels". Postmortem evidence from the last C. fleckeri fatality demonstrated nematocyst barbs penetrating the vascular dermis. C. fleckeri venom has haemolytic, lethal, myotoxic and dermonecrotic effects. Current evidence suggests that the venom toxins are proteinaceous and target specific organs. Monoclonal antibodies capable of neutralising C. fleckeri-induced haemolysis did not protect against the lethal effects of venom. Several myotoxins, with molecular weights of about 600 kDa and 150 kDa, have been reported in C fleckeri venom. These toxins showed significant lethality in a mouse model of envenomation and may play a role in human cardiotoxicity. We speculate that these and other, as yet unidentified, proteins cause ion flux and transmitter release through altering cell membrane permeability, either through specific interactions with ion-channels or receptors or through non-specific interactions with cell membranes. Charmers... And thank god I don't live in that region __________________