Silent Hunter 4 FOTRS crashes on entering mission

[propbeanie]

Well, I cannot get your 1st image to open, and the 2nd is quite small, but is somewhat legible. You could try clearing the tick in Run as admin and then try clearing the "Disable fullscreen optimizations" and see what happens. You will almost always have to use the "Change high DPI settings" button, and then "Override high DPI scaling behavior" and set to Application.

Also, you mention FOTRS, which is an AOTD_MadMax mod. There is also the FotRSU Fall of the Rising Sun Ultimate edition that is a combination of all of MadMax's version of FOTRS into one, and more added to it. Most of the mods require Silent Hunter v1.5 aka: Gold Edition aka: U-Boat Missions. Only FOTRS v2.x will run on SH4 v1.4. All others require v1.5 of the game. Plus, you cannot have the game installed in a Program Files folder. You can run JSGME, click on the "Tasks..." link in the middle of the app, and "Export activated mods list to" and choose Clipboard or Text File. Paste the information into your next post, and someone can possibly get you further along.