Can I Manually Install Mods?

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Can I manually Install mods into SH5?

Yes by using JSGME check out my tutorials.
You can install any mods with Steam.

I ask because After watching a video of Open Horizons being installed in such a way (unspecified whether or not is was a steam version)

Irrelevant as I said.

Steam fix for using TDW's Generic File Patcher essential application.
Post #161 TDW’s Generic File Patcher Steam Installation Instructions By sirrawsrsalot > Updated Version

TDW Generic Patcher seems like the Foundation Mod

Not a mod its an application and can be installed as a stand alone anywhere or enabled from within TDW's NewUI 7-5-0 base mod.

Vanilla is bugged and broken.

Use one of the mega mods like sobers or TWOS after converting the Steam application.
Making your own mod lists is not worth the time or trouble as you will spend more time fixing it than playing the game.
The mega mods are very reliable.
Peter