SH4 Runs on 27" But Refuses 43" Monitor

Greetings Mates!

Yup, got a Samsung 43" curved UHD display and everything runs great and works as it should - except SH4. When clicking within the start menu the little Windows wheel starts turning then stops after about 3 seconds. No error messages at all. It simply fails to launch. The steps I've taken are as follows;

1. With the 43" monitor still attached, deleted SH4 entirely, including cleaning out the registry and reinstalled the game to my G (gaming) drive, no launch.
2. Tried running the .exe as administrator within the SH4 file folder, no launch.
3. Set my 27" monitor beside the 43", plugged the HDMI cable from the 43" back to the 27", SH4 launches fine. Go back and plug the HDMI back into the 43" and try launching it again, no launch.

Obviously there is something about running SH4 on the bigger monitor it doesn't like, but for the life of me can't figure out why it won't even launch with that monitor hooked up, let alone run. I'm running SH4 at the 2560x1440 resolution when it runs on the 27" monitor. I would think it would at least launch on the bigger monitor.

My system specs my help someone narrow it down;


Windows 10 (SH4 for me runs fine unlike some other posts I've seen) 64bit
I7 5390k 6 core 3.5Ghz
GTX 780ti
16 GB DDR5
SSD drive
ASUS 27" UHD 3D monitor
Samsung 43" KU7500 UHD monitor

Thank you everyone. I'd really like to get SH4 going again!