Do not install in a Program Files folder
Be sure and DO install DirectX v9.0c and the Media Codecs
With the DVD, you don't have to bother with Game Shadow nor Acrobat...
I did not have any issues at all with my UPlay SH4 install on a fully-updated Windows 10 64-bit. The installer picked everything up just fine, but as the install dialog got to the part of where to install the game, I deleted the "\Program Files (x86)" portion of the path from the dialog box, and have my game in "C:\Ubisoft \Silent Hunter..."