I am not certain this would work for an SH5 UPlay version, but I have copied my SH4 UPlay and my Steam SH5 and SH3 to different folders before I patch and / or mod them (SH4 does not have any exe patches). I leave the installed copy of the game as-is. Also, it is important to NOT install into a Program Files folder. But after I install the Stock game, I then copy the entire install inside of the game folder, and paste those contents into a folder of my own choosing elsewhere on the hard drive. Then I do my editing there, and the original install then is the one that the UPlay or Steam app can mess with all they want to. I also do not use the SH4 UPlay shortcut, starting directly from the SH4.exe file. There might be different security on the SH5 game though, and that might not work, I don't know...
