It runs rather well on Win10, but you do have to make some changes to a few things. The best all-round thread for info would be THEBERBSTER's
SH4 <> TUTORIALS <> HOW TO DO IT <> INFO <> DOWNLOAD LINKS -STICKY INDEX - up near the top of that is his "banner" for "Important Information For Windows 10 Problem Solving". One of the pages linked to further down that page is CapnScurvy's
Windows10; Large Address Aware; SH4 Install, which touches on a lot of subjects having to do with Win10 & SH4 - highly recommended for what you have now.