I had something more basic on mind, Rick. Like first destroying natural habitats, by that bringing relations between predators and prey off balance, and then wondering why the ecosphere is going over the cliff. Or like introducing a foreign species into another country, continent, where it spreads like crazy since it has no niche in the ecosystem - and due to that messing up the ecosystem for all other species as well. Ask the Australians. They can sing a song of this, going back to when the British colonized the continent and thought they must rearrange nature a bit down there, both zoologically and botanically. The disastrous consequences from that can still be seen and felt until today.
Nature is a perfect self-regulator, for hundreds of thousands of years. If left to itself, it regulates its business better than man ever could. In non-static but fluctuating, dynamic balances maybe, but still.
On Australia, Jared Diamond has a great summarizing chapter of roughly 50 pages about the problems I hinted at in his highly recommendable book
"Collapse" (LINK). There he gives many other exmaples on societies around the globe who messed up their surrounding ecosystems by overfishing and overhunting, and by that destroyed themselves in the end.