Apologies for the late response, gentlemen.
@Peter - yes, I simply moved the installed game to another drive.
So I will uninstall Uplay & SH5 and use CCcleaner as recommended by you guys. Once I've completed that, will do a clean install (but not in the x86 prog folder) and then apply:
http://www.mediafire.com/file/hvdw0i..._Test.exe/file
Thanks for quickly taking the time out to help.
Edit: Unfortunately this hasn't worked. If I launch through the SH5.exe, it asks for my CD key (which I lost ages ago). If I launch through Uplay, I get the usual ctd after the splash screen with the small radar icon bottom right has loaded.