If it's a matter of space you can install steam and move DW over to the thumb drive and link it with mklink.
LinK187 (post #7) has a nice easy guide on that over on the steam forums.
http://forums.steampowered.com/forum...d.php?t=664376
Quote:
For this to actually work properly for vista users:
-Copy the game folder to the destination you want.
-DELETE the entire game folder from it's original location or the command will produce an error.
-run cmd.exe as administrator
use the command: mklink /J "C:\junction folder\game" "D:\actual folder\game"
it will create a folder where the old one was but it will have a little arrow thingy on the bottom left corner of the folder icon. Essentially a shortcut folder. Now you don't have to buy bigger hard drives or uninstall games or wait for steam to finally have this functionality built in.
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EDIT: Won't work if you don't have DW on steam.
EDIT PT2: With the steam version, removing the registry keys entirely seems to have no effect. I'm running the game off an external hard drive as it is, so you may be able to get the game running without the keys too. I've lost my retail disks though so I can't say whether or not it'll work with them. I can't imagine it would hurt to try.