MIDI is Musical Instrument Digital Interface, where samples of over 100 instruments are stored on your computer and the MIDI system can play them. Because of the strict mathematical precision of MIDI and the "sloppy" human way of rendering music, MIDI always sounded mechanical and lifeless to most people. After a huge surge in enthusiasm through the 90s, MIDI has fallen into less popular use.
Many games still use it to great effect, however, and skillful people can make MIDI really shine. I wouldn't worry about a program wanting to issue instructions on how to play a bunch of virtual instruments. What e-mail program are you using that is requesting MIDI access?
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