[minsc_tdp]

Abraxus - the fact that it works in notepad or windowed demonstrates how it works - it issues keystroke and mouse commands to the general OS. If a window is focused or fullscreen, it gets the command. This could be an unusual keyboard driver, but that's very unlikely to affect the mouse-based command unless they're some kind of combo unit or made by the same manufacturer. You might try uninstalling your existing keyboard and mouse drivers and any software associated with them, let Windows install the normal HID drivers, and try again. The drivers might be detecting fullscreen mode and doing some tricks to disable certain keys from the OS (such as the windows key) and in so doing, interfering with shSpeech.