Assuming there's no other underlying issues going on, my best advice would be to avoid scrolling the map at high time compression. At least on my last install this always gave a significant drop in frame rate. You can test it by pressing ctrl+F8 - you'll see a tiny frame counter at the top of the screen. If that's the case and something happens to spawn in at that exact moment, then guaranteed CTD. Additionally, I've always believed the issue to be more prevalent if using the mouse to move the map. Better to use the arrow keys. Of course, this is just my conjecture.
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