Personally I wouldn't bother with a south paw reciever unless you were left eye And left hand dominate, and the rifle in question was "The" rifle.
Thankfully, I'm right eye and hand dominate so i never had to give this subject much thought. My wife is right handed but left eye dominate, which at times in the past was somewhat amusing once we figured out what the problem was.
EDIT:
It occurs to me, the lefty's dream rifle in an intermediate cartridge is probably an IWI Tavor. That thing is wicked slick, and truly ambidextrous.
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