If the zombies roamed, I'd probably break into a police station to arm myself, find a horse to ride into a major city, and once my horse was eaten I'd hook up with a group of survivors only to find my wife and my best friend with them. We'd make it to the CDC in Atlanta, blow the place up, then find a cozy little farm in the outskirts of the country. A simmering resntment towards my best friend would lead to me killing him, and roving herds of zombies would force us to flee and take shelter in a prison near a cult-ish survivor camp.
That's probably how it'd go down.
