For some reason the settings do not stick when you launch the game.
Try exiting the autostart menu and make your settings then. Start the game from the desktop shortcut and see if they stick.
Or try to make a new program profile to your sh3.exe in nVidia control panel.
Make you're settings and launch the game. That has worked for me and others before.
Or try installing the drivers again, that has also worked:hmm:
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