The Sakura mod, I don't think makes a difference in the campaign unless there are missions in the campaigns that involve oil rigs (unsure of that as I havn't progressed through the entire series of campaigns with all the platforms yet). As far as LWAMI, I know that it makes a small handfull of missions in the stock campaign VERY difficult but 99% of all custom made missions are made for LWAMI. LWAMI comes with the Generic Mod Enabler program so you can turn the mod on and off as you want to without a fus. You can set it up so it does the same with the Sakura mod as well. Install LWAMI before the Sakura Mod so the generic mod enabler goes in first.
