[Von Manteuffel]

The best solution is:

1. Completely uninstall SH3 using the "Uninstall" option from the game Dvd
2. Manually delete any remaining SH3 folder and contents from Program Files\Ubisoft
3. Manually delete the SH3 folder and contents from your "My Documents" folder.
4. Run a good Registry Cleaner.
5. Reboot
6. Re-install SH3 from the disc - Check version 1.1 plays
7. Patch to Version 1.4b - Check it Plays
8. Install GWX2 - Check it plays
9. Install GWX 2.1 Check it plays.
10. Install SH3 Commander ( if required )
11. Install any required mods using JSGME ( It;s installed automatically with GWX2)
12. Enjoy.