If we became non-interventionist and were willing to trade with Iran freely and not back nations that have strained relationships with them then no it would not be neccessary.
If we continue to support Israel and maintain presence and/or support of Iraq I can see trouble ahead.
It's kind of a lose-lose situation; either we stay the hell out of Middle Eastern affairs so as to appease them and place our allies and other nations in jeopardy, or we play policeman and piss off Iran. And I'm certain that either way some extremist or another will be mad at us for either decision.
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I stole this sig from Task Force 
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