Should be, as long as you run Windows on the Mac
The compiled code is windows only, so it will not run under OS X. But a Mac with a NVidia or ATI graphics set should work, and you could run windows as a dual-boot setup, or in a something like Parallels which lets it run simultaneously with OS X.
I use Macs and OS X for just about everything (have been a Mac user since system 6 days). The only reason I even have a windows box is, well, for SHIII, SHIV and some flight sims.