Don't be so swift to blame Vista for this issue. I am inclined to belive it is an issue with the vista version of Nvidias Graphics driver. I run something to the effect of 50 Games on my vista systems with no troubles. This is actually the only game I've run into issues with, and at that only when Running a mod.
I play Everything from Supcom to penny arcade adventures to Master of Magic and Galactic Civilations, Halflife to Team Fortress 2 and Crysis.
As for this Issue, at least for me Switching to an Older Driver (v163.75) Stopped the BlSOD's and Instead just CTD'd while Disabling Post Processing Effects has elimminated the CTD.
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