Mods aren't effected by your screen resolution. The only thing Res10 Fix is not compatible with is Fraps(causes ctd). Otherwise, as long as your system can handle the crisper graphics from supermods such as GWX and WAC 2.15 Full Version, you should have no problem.
BTW, you made a wise choice getting Uboat 1.2. I love it. JCWolf's graphics work is top notch, I wouldn't play SH3 without this mod.
Happy hunting
