:hmm: I remember a thread re. tweaking graphics settings for SH3 and found nHancer "broke" my nPanel... Had to work pretty hard to get rid of that thing again...
Try using ccleaner after removing nHancer and old nVidea drivers before updating to newest 169.21 and newest nPanel.
I was never pleased with what nHancer and the tweakings could give or at least in my case it did not improve anything. Have been using 169.21 and nPanel since then and can't be happier.
Especially with the new GWX 2.1 scene...
Good luck!