Runs like a dream for me, running Trigger Maru Overhaul and 1.5 on a quad core 3.2GHZ, 4GB 800mhz RAM, 2x 8800GTX in SLI, 2x 500GB SATA HDDs, 1000whz ultra cool psu with Vista 32bit.
I DID have some graphics driver issues with the 8800s in SLI about 8 months ago, but other then that my system has been really reliable and runs perfectly, unlike my old XP system!
V