I had a similar issue just this weekend, I use 64 bit Vista. Every time I tried to load my mid mission save, the program would become unresponsive and Vista would crash/close it.
I had saved the game while TC was set to 0 though, I was in the middle of something and didn't want time to move when I came back, I think I was right on top of a ship or something. Anway, I wondered if the TC = 0 thing would cause any problems, bug figured it wouldn't.
I haven't tested it yet, but that was the first time I had ANY problems with SH4 at all, and I was able to load my save from leaving the port with no problems, so I'm currently attributing it to having saved while TC was set at 0.
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