I have run into this issue.
Using patch 1.4 = rock solid
Install U-Boat missions add-on
Blue screen, as soon as torpedo strikes target
The sound goes into a loop, i'll get a black screen, with the game screen popping back up a couple of times (that would be the graphics driver attempting to reset)
and then blue screen
Gone back to 1.4, and it's rock solid stable again
All my other games that seriously stress the graphics card are stable (eg - Crysis)
I'm using
Vista Home Premium
Motherboard: Asus P5N32-E (using latest BIOS)
NVIDIA GeForce 8800 Ultra (driver 169.25)
RAM: 2046Mb