I have almost identical system as you (I have a GTX instead of a GTS). I ran Silent Hunter 4 v1.4 no problem in Vista 64 Ultimate. If it asks you to install DirectX 9 drivers you must allow it since this game (and many others) require DirectX 9 to run.
Black screen after intro is a possible codec issue? Some people have had problems with the K-Lite codec pack, and some others that result in a black screen intro. Do you have a codec pack installed?
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