Thanks for the suggestions, although what I meant was I'd already tried all those that everyone posted and they were not working; whatever I put the settings on, it was saying that my browser wasn't storing cookies properly (god knows why that might be) so I was looking for other obscure stuff that anyone might know.
Anyway, it seems nothing was going to sort it, obviously something was really screwed because it wouldn't even update via MS security updates, which is generally a bad sign, so I decided to delete it and re-install a different version (which fortunately I already had on another drive), and that seems to have got around the problem, as all the privacy and trusted site stuff is now working how it should. Although now my copy of AdAware thinks I'm a hacker, so it won't fire up:rotfl:
But hopefully I can sort that one out, I just emailed Lavasoft about it. So cheers all.
Chock