Ditto here on Vista.... do as the others say, install in the root of the drive and run as admin. Also make sure they are patched AND YOU KEEP UP WITH THE DRIVER UPDATES!!! Especially if you have an NV Graphics card.
I have both SHIII and IV installed in a "SilentHunter" folder on the root of my C and they both run sweet
AMD dual Core +4800
GT8600
Viewsonic VX2025WM running at 1680 x 1050
4 Gig
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