Krauter,
Yes it is Vista, and there is a solution.
Vista by default does not let normal Administrative users write files under the Program Files directory. However, in order to keep applications that used to do this from breaking, it will redirect writes in this directory silently to another path somewhere else (can't remember exactly where off the top of my head).
To fix this, open notepad by right-clicking the shortcut and selecting "run elevated". This will make the silent redirection not apply to notepad during its lifetime. Then open the file you want to edit in that instance of notepad and it should save fine.
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