No one bomber can replace all the current Bombers, and all their rolls. So I think they should be looking to procure a base airframe, which can be modified to carry out one of the three mission profiles you describe. Say a difference between the wing types, and the engine types used on the base airframe to determin which mission profile it will fill.
However, I don't imagine large B-52 like bombers unless they go with the "bomb truck" idea which has been bounced around. And if they go with that idea, they would be sitting ducks for any air engagement.
The FB-22 Idea that some have proposed is to small . . .
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