You've got to have a really strong machine then, right ?
I havn't even enabled 3D Acceleration under Linux as I won't use it anyways.
Played Tropico once under wine but it was slower than under Windows so I don't even try something of the caliber of SH3

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But having Windows installed for some games is not that bad. For 2 hours of playing I don't care about 2mins of booting.