Have you checked that your system meets the minimum spec for the game? SH IV is very "hungry."
If your set-up meets the specs, I can only suggest a total uninstall and a full reinstall:
I would also check that you end all unnecessary processes and switch off anti-virus if you use it before running the game.
Start with the basic "out of box" game and see if it runs. If it does .....
Download and install patch 1.3 and run the game. If that works install JSGME and then mods, checking that the game runs with each one.
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