On an un-modded and without the no-CD crack and the CD in the drive, you should be able to go from a clean install of the game directly to patch 1.2 (and soon 1.3.)
You cannot use any in-game saves after applying any patch. You have to start from a home base auto-save. If you are in a campaign now you don't want to lose, return to base, then apply the latest patch. As the readme documentation for the patches mention, the patches are cumulative and retro-active. I suggest jumping right into patch 1.2 as the improvements are significant over 1.1.
-Pv-
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