If you only occasionally start getting it all of a sudden, then minimize your game to the taskbar, wait a few sec (best let your system calm down), then maximize it again. Fixed.
At least works for me. Don't know if that was the fix you were talking about, but it fixes it for me.
If the mouse is always laggy, then your gfx settings are too high. Turn environmental effects off for starters or reduce gfx quality in your gfx card settings outside the game.
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