Yes, it's fully Vista compatible and it works like a charm. No decreased performance. I'm using Vista Ultimate edition.
From the SH4 readme:
-Minimum Configuration:
WinXP/VISTA Only
DirectX 9.0c
2 GHz Pentium 4, AMD Athlon, or equivalent
1024 MB RAM
128MB DirectX 9.0c compatible graphics card with Pixel Shader 2.0 capability
DirectX 9.0C compatible sound device
DVD-ROM 4x or faster
6.0 GB hard drive space
Windows-compatible mouse required
Internet connection for play on Ubi.com (minimum 56k modem or broadband)
-Recommended Configuration:
Win XP/VISTA Only
DirectX 9.0c
3 GHz Pentium 4, AMD Athlon or equivalent
2048 MB RAM
256MB DirectX 9.0c compatible graphics card with Pixel Shader 2.0 capability
DirectX 9.0c compatible sound device
DVD-ROM 4x or faster
6.0 GB hard drive space
Windows-compatible mouse required
Internet connection for play on Ubi.com (minimum 56k modem or broadband)
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