You need to use JSGME to enable the patch. To do this you need:
1. Extract the patch into C\Program Files\Ubisoft\SH3\MODS
2. Run the JSGME from C\Program Files\Ubisoft\SH3 and disable all the mods you're running. After that enable the patch and after the patch enable all other mods you want.
3. You're ready. Now go and sink someone