I don't know why a lot of people are talking about "uber" destroyers in GWX just because they are not sitting ducks anymore... I don't find them more dangerous than in NYGM. You just need to have a little respect and try to stay away when you are not in a good position, which means that like in real life there will be many times where you will have to hide and run instead of attacking, and show some patience to wait for the good opportunities. Bad weather is your friend as long as there is no heavy fog associated with it...
Attacking escorted freighters by daylight and nice weather can bring you in a lot of trouble...