Two to four MK48's will do the trick normaly unless your in a 688i then fire a whole batch the 12 VLS tubes and the four torp tubes of TASM and be close. the nimitz cant combat them all.
Chances are with that though you will find it will swat 2/3 or them but one lucky one or two will get in damaging it sufficently that it cant use its weapons.
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