I was being a little light-hearted (light-headed?), but you're right; it's not really 100% safe ever. Once during a patrol I was exiting and using SHIII Commander to change fatigue models-repeatedly. I had no problems at all, but then I didn't care about that patrol anyway; I was just experimenting.
It's always a good idea to wait until you're in port to change anything. If you want to see how it worked, load up a single mission. That way there's nothing to lose.
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“Never do anything you can't take back.”
—Rocky Russo
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