With enough fuel tanks I suppose it could reach Israel, but then it would have to go through this:
http://www.iaf.org.il/Templates/Airc...ntPageNumber=6
And this:
http://www.iaf.org.il/Templates/Airc...ntPageNumber=5
And this:
http://www.iaf.org.il/Templates/Airc...ntPageNumber=5
And this:
http://www.iaf.org.il/Templates/Airc...ntPageNumber=5
And the fighters.
1 F-16 might not be able to destroy 50 Me-262 but it can outright kill up to 6 of them with missiles. Then it could either escape unscratched or engage with Guns, in this case it could still pick out a few 262s untill there were no more vulnerable planes or gaps in their "formation".
There would be a kamikaze use for this plane against Naval ships. Of course, if the Iranians have such strategies, perhaps, say, the Americans are also thinking of strategies to defeat kamikazes? Here's one: destroy all these planes on the ground with F-117s and B-2s on the first night of the campaign.
This reminds me of the AAA guns in Baghdad. There was this "military expert" warning about the 40mm Bofors and other guns because "pointed to the ground they could annihilate the American soldiers". He forgot the Air Force could destroy these guns. Is this the case here?