The Hamas-run health ministry in Gaza told Reuters 14 people were killed in a blast at al-Mawasi near Khan Younis.
Al-Mawasi, which is about the size of London's Heathrow airport, has been designated a safe zone in Gaza by Israeli forces.
The Israeli military has not yet commented on Hamas's claims.
The funeral of Hamas deputy leader Saleh al-Arouri - who was killed in Lebanon by a suspected Israeli drone strike - is taking place in Beirut.
At least 1,200 people were killed when Hamas attacked Israel on 7 October and about 240 others were taken hostage.
The Hamas-run health ministry in Gaza says more than 22,000 people have been killed in the territory since Israel started its retaliatory campaign.
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