Israeli armoured vehicles have been seen on the main road running from north to south of the Gaza Strip, close to Gaza City.
The Israeli military has said they will not comment on the location of their forces.
But it comes as Israel expands its ground offensive in Gaza, with a military spokesman saying troops killed "dozens of terrorists" during clashes overnight.
Meanwhile, "hundreds and hundreds of patients" are stuck in hospitals in the north of Gaza, the UN agency for Palestinian refugees says.
Doctors say Israel told staff to evacuate Al-Quds hospital in Gaza City on Sunday but that moving patients - many of whom are in intensive care - is impossible.
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Wise men speak because they have something to say; Fools because they have to say something.
Oh my God, not again!!
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