You probably need to tick that "Disable full-screen optimizations" on the main Properties page, and then tick the "Override high DPI scaling behavior..." on the upper window, and set it to "Application" in the drop-down box NST7.
GWX has a GUI, the different WS mods have their own GUIs, Onealex's mod has its own GUI, as does Anvar1061's GWR2020. Most mods do alter the interface. Some GUIs are 1024x768, 1920x1080, 1355x768, etc. In the case of your display screen you are at double what the 1920x1080 is, which is a 16:9 ratio. 1024x768 is 5:4, hence the stretch distortion you see, as Jeff-Groves noted.
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