Until you return to port, you cannot change certain settings and have them take effect (unless you noodle in the Save folder and risk CTD). Just don't forget that the Main Menu's "Options" are different from the ones in the Captain's Office in the Career Mode, and that each career can have a different set of Options, and must be set each time you begin a new career. Use the wooden radio console to the left in the Captain's Office in port to change things in each of your careers.
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