Health Secretary Sajid Javid says he has tested positive for Covid-19 and is suffering "very mild" symptoms.
Mr Javid, who said he had received both vaccine doses, took a lateral flow test on Saturday morning after feeling a "bit groggy" on Friday night and it came back positive.
He said he is now self-isolating until he gets the results of a PCR test.
Meanwhile, England's deputy chief medical officer, Prof Jonathan Van-Tam, has warned of a "bumpy winter" ahead.
It comes as the UK recorded more than 50,000 daily cases for the second day running, days before almost all legal restrictions on social contact are lifted in England on Monday.
There were 54,674 cases, compared to 51,870 cases on Friday. There were 41 deaths within 28 days of a positive coronavirus test.
The last time cases exceeded 50,000 was in mid-January.
https://www.bbc.co.uk/news/uk-57874744