How far along are you in your campaign? And do you save frequently?
I got from 1939 to 1943 in one campaign and all of a sudden my saves stopped loading, I had been saving frequently across many patrols and giving each of them a different name. I'm not sure why but as time went on these save files grew bigger until the point where the save folder was hundreds of megabytes big, I managed to prevent this happening on a subsequent campaign by saving over my previous files rather than naming each one something unique. If you save too frequently across a long campaign I have found that the game struggles loading saves so it may be a good idea to start over copying across the data from your last save into the first save of a new campaign so you retain your progress.
If you have changed any mods whilst out of port this can cause crashes to desktop when loading saves.
Try running SH3.exe in compatibility mode for Windows XP (Service Pack 2), I had loads of crashes to desktop on loading saves before doing this. And of course the 4gb patch if you haven't installed it.
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