A national lockdown, or "firebreak", begins in Wales at 18:00 BST - and will last until 9 November.
It means people must stay at home, and pubs, restaurants and non-essential shops have been ordered to close.
In Scotland, First Minister Nicola Sturgeon has set out a new five-tier alert system to come into force on 2 November.
Tough new measures are in place in Greater Manchester, and Warrington will move to England's highest tier next week.
A further 20,530 people test positive for Covid-19 in the UK, and there were 224 more deaths.
New daily coronavirus cases in England doubled in a fortnight but the growth rate may be slowing, data suggests.
US regulators given full approval for the antiviral drug remdesivir to treat Covid-19 patients in hospitals.
France is extending an overnight curfew to dozens more areas.
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Oh my God, not again!!
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