President Trump is in hospital after being diagnosed with coronavirus.
The White House said the move was out of an "abundance of caution" and his doctor said he was "doing very well"
Ex-adviser Kellyanne Conway, campaign manager Bill Stepien and two Republican senators - Mike Lee and Thom Tillis - all test positive.
Joe Biden, who debated the now Covid-positive US president on Tuesday, has tested negative.
First Lady Melania Trump also has the virus and is recuperating at the White House.
Trump, 74, has been criticised for playing down severity of virus and often spurning masks and social distancing.
In other news, more than a third of the UK's population are now under heightened restrictions.
More than 34 million cases have been confirmed globally with around 1.02 million deaths, Johns Hopkins University says.
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